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TribioScience | SKU: TBI1207-10UG

Xestospongin C, Inhibits IP3-mediated Ca2+ release (TBI1207)

Name: Xestospongin C, Inhibits IP3-mediated Ca2+ release (TBI1207)
Brand: TribioScience
SKU: TBI1207-10UG
Price: 135.0 USD
Availability: InStock

$135.00

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TribioScience

Xestospongin C, Inhibits IP3-mediated Ca2+ release (TBI1207)

From $135.00

Description

Product Details

Formal Name: Natural product isolated from the marine sponge Xestospongia sp.

Molecular Formula: C₂₈H₅₀N₂O₂

Formula Weight: 446.70

CAS Number: 88903-69-9

Purity: >97%

Formulation: Lyophilized

Solubility: Soluble in DMSO (up to 10 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Inhibits IP3-mediated Ca2+ release

Functions

A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+ and K+ currents at a concentration range similar to that at which it inhibits the IP3 receptor. It is a useful tool for probing the involvement of IP3 receptors in cellular signaling. Cell permeable.