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TribioScience  |  SKU: TBI1137-50MG

WY-14643, PPARα agonist (TBI1137)

$117.00
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TribioScience

WY-14643, PPARα agonist (TBI1137)

From $117.00

Description

Product Details

Formal Name: 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid

Alternate Names: Pirinixic acid

Molecular Formula: C14H14ClN2O2S

Formula Weight: 323.80

CAS Number: 50892-23-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

PPARa agonist

Functions

Selective PPARα agonist (EC50=0.63, 32 and >100 µM for PPARα,γ and δ, respectively). Displays anti-inflammatory activity and reduces LPS-induced inflammation in alveolar epithelial cells. Induces “browning” of white adipocytes in combined treatment with retinoic acid. Stimulates ADAM10-mediated proteolysis of amyloid precursor protein in a mouse model. Down regulates NFκB transcriptional activity. Review.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.

Option

  • 50 MG
  • 250 MG
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