WP-1130, DUB inhibitor (TBI1351)

Description

Product Details

Formal Name: (S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide

Alternate Names: Degrasyn

Molecular Formula: C₁₉H₁₈BrN₃O

Formula Weight: 384.28

CAS Number: 856243-80-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

DUB inhibitor

Functions

A novel DUB inhibitor directly inhibiting USP9x, USP5, USP14 and UCH37 inducing rapid accumulation of polyubiquitinated proteins. Triggers tumor cell apoptosis. Blocks Jak2 signaling via Jak2 ubiquitination. Causes ablation of the oncogenic transcription factor ERG in prostate cancer cells.

Application Procedures

First dissolved in DMSO (up to 45 mg/ml), or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.