VE-821, ATR inhibitor (TBI5589)

Description

Product Details

Formal Name: 3-Amino-6-[4-(methlsulfonyl)phenyl)-N-phenyl-2-pyrazinecarboxamide

Molecular Formula: C₁₈H₁₆N₄O₃S

Formula Weight: 368.40

CAS Number: 1232410-49-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

ATR inhibitor

Functions

A potent and selective ATP-competitive ATR (Ataxia-telangiectasia and Rad3-related protein) inhibitor, Ki=13 nM. Increases the sensitivity of pancreatic and ovarian cancer cells to radiation and chemotherapy. Increased replication stress induced by PARP inhibitors or chemotherapeutic agents increases sensitivity to VE-821 in neuroblastoma cells. Enhances the cytotoxicity of DNA damaging agents.

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.