Vandetanib, VEGFRK inhibitor (TBI2185)

Description

Product Details

Formal Name: 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-yl)methoxy]quinazoline

Alternate Names: ZD6474

Molecular Formula: C₂₂H₂₄BrFN₄O₂

Formula Weight: 475.40

CAS Number: 443913-73-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

VEGFRK inhibitor

Functions

A potent and selective inhibitor of VEGFR2, (KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Inhibits colony formation in seven cancer cell lines. Displays anti-angiogenesis activity.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.