Valsartan, Angiotensin AT1 receptor antagonist (TBI2052)

Description

Product Details

Formal Name: (S)-3-methyl-2-[N-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-pentanamido]butanoic acid

Alternate Names: CGP-48933

Molecular Formula: C₂₄H₂₉N₅O₃

Formula Weight: 435.52

CAS Number: 137862-53-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 40 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

Angiotensin AT1 receptor antagonist

Functions

High affinity angiotensin AT1 receptor antagonist (Ki = 2.38 nM). Highly selective (30,000-fold) over AT2 receptors. Normalizes the increased production of inflammatory cytokines in adipose and liver tissue in LPS-infused mice. Clinically useful antihypertensive agent. Orally active.

Application Procedures

First dissolved in DMSO (up to 40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.