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TribioScience | SKU: TBI4880-5MG

UCPH-101, EAAT1 inhibitor (TBI4880)

Name: UCPH-101, EAAT1 inhibitor (TBI4880)
Brand: TribioScience
SKU: TBI4880-5MG
Price: 162.0 USD
Availability: InStock

$162.00

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Product Description

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TribioScience

UCPH-101, EAAT1 inhibitor (TBI4880)

From $162.00

Description

Product Details

Formal Name: 2-Amino-4-(4-methoxyphenyl)-7-naphthalen-1-yl-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile

Molecular Formula: C₂₇H₂₂N₂O₃

Formula Weight: 422.48

CAS Number: 1118460-77-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

EAAT1 inhibitor

Functions

UCPH-101 is a potent (IC50 = 660 nM) and selective inhibitor of the excitatory amino acid transporter 1 (EAAT1). It induced cell death in glioblastoma cells via intracellular glutamate accumulation. UCPH-101 also significantly increased survival in glioma-bearing mice.