Tubastatin A HCl, HDAC6 inhibitor (TBI4530)

Description

Product Details

Formal Name: N-Hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide hydrochloride

Molecular Formula: C₂₀H₂₂N₃O₂ · HCl

Formula Weight: 371.86

CAS Number: 1310693-92-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

HDAC6 inhibitor

Functions

Potent and selective histone deacetylase 6 (HDAC6) inhibitor, IC50=15 nM (>1000-fold selective against other HDACs and 60-fold for HDAC8). Inhibits TNF-α (IC50=272 nM) and IL-6 (IC50=712 nM) in LPS-stimulated human macrophages and displays anti-inflammatory activity in animal models. Improves survival in animal models of sepsis. Improves cognition in Alzheimers disease transgenic mice. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.