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TribioScience | SKU: TBI2228-5MG

Tryptanthrin, Immunomodulator; IDO2 inhibitor (TBI2228)

Name: Tryptanthrin, Immunomodulator; IDO2 inhibitor (TBI2228)
Brand: TribioScience
SKU: TBI2228-5MG
Price: 99.0 USD
Availability: InStock

$99.00

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Product Description

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TribioScience

Tryptanthrin, Immunomodulator; IDO2 inhibitor (TBI2228)

From $99.00

Description

Product Details

Formal Name: Indolo(2,1-b)quinazoline-6,12-dione

Alternate Names: NSC 349447; Couroupitine A

Molecular Formula: C₁₅H₈N₂O₂

Formula Weight: 248.24

CAS Number: 13220-57-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Immunomodulator; IDO2 inhibitor

Functions

A indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1 Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling. Displays antiinflammatory activity targeting IL-17. Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 μM. Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

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