Tolcapone, COMT inhibitor; TTR aggregation inhibitor (TBI3075)

Description

Product Details

Formal Name: (3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone

Molecular Formula: C₁₄H₁₁NO₅

Formula Weight: 273.24

CAS Number: 134308-13-7

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

COMT inhibitor; TTR aggregation inhibitor

Functions

Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo. Inhibits O-methylation of exogenous polyphenols such as EGCG. Cell permeable. Orally bioavailable.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.