Tofacitinib, JAK inhibitor (TBI2177)

Description

Product Details

Formal Name: (3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-β-oxo-1-piperidine-propanenitrile

Alternate Names: Tasocitinib; CP-690550

Molecular Formula: C₁₆H₂₀N₆O

Formula Weight: 312.40

CAS Number: 477600-75-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

JAK inhibitor

Functions

Potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively. Displays potent antiinflammatory and immunosuppressant activity. Promotes a white-to-brown metabolic conversion in human adipocytes. In therapeutic use for rheumatoid arthritis.

Application Procedures

First dissolved in DMSO (up to 100 mg/ml) or in Ethanol (up to 100 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.