TM-2-51, HDAC8 activator (TBI1522)

Description

Product Details

Formal Name: 1-Benzoyl-3-phenyl-2-thiourea

Molecular Formula: C₁₄H₁₂N₂OS

Formula Weight: 256.32

CAS Number: 4921-82-8

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

HDAC8 activator

Functions

Highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. Rescues the activity of catalytically compromised HDAC8 mutants in vitro.

Application Procedures

First dissolved in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.