Tianeptine Na, Neuroprotective agent (TBI2937)

Description

Product Details

Formal Name: 7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidibenzo[c,f][1,2]thiazepin-11-yl)amino]heptamoic acid, sodium salt

Molecular Formula: C₂₁H₂₄ClN₂O₄S Na

Formula Weight: 458.93

CAS Number: 30123-17-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 5 mg/ml) or in Water (up to 45 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

Neuroprotective agent

Functions

Selective enhancer of serotonin uptake in the brain with no effect on noradrenalin or dopamine uptake. Clinically useful antidepressant. Displays neuroprotective effects against hypoxia in cell culture and against the deleterious effects of cytokines in vivo. Induces mTORC1 activation in rat hippocampal neurons and increases dendritic outgrowth, spine density and synaptic proteins. Attenuates LPS-evoked inflammatory activation of microglial cells in culture.

Application Procedures

First dissolved in DMSO (up to 5 mg/ml) or in Water (up to 45 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.