Tiagabine HCl, GABA transporter 1 (GAT1) inhibitor (TBI4384)

Description

Product Details

Formal Name: (3R)-1-[4,4-Bis(3-methylthiophen-2-yl)but-3-enyl]piperidine-3-carboxylic acid hydrochloride

Alternate Names: NO-325

Molecular Formula: C₂₀H₂₅NO₂S₂·HCl

Formula Weight: 412.00

CAS Number: 145821-59-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

GABA transporter 1 (GAT1) inhibitor

Functions

Tiagabine is a clinically useful anticonvulsant. It is also used to treat anxiety/panic disorder and neuropathic pain. Inhibits GABA-reuptake (IC50 [3H]GABA uptake = 67 nM) via inhibiting GABA transporter 1(GAT1) blocking both neuronal and glial GABA re-uptake.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), in Ethanol (up to at least 25 mg/ml) or in Water (up to at least 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO, ethanol or distilled water may be stored at -20°C for up to 3 months.