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TribioScience  |  SKU: TBI1546-10MG

TGN-020, Aquaporin 4 blocker (TBI1546)

$135.00
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TribioScience

TGN-020, Aquaporin 4 blocker (TBI1546)

From $135.00

Description

Product Details

Formal Name: N-1,3,4-thiadiazol-2-yl-3-pyridinecarboxamide

Molecular Formula: C8H6N4OS

Formula Weight: 206.22

CAS Number: 51987-99-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 10 mg/ml with warming)

Storage: Room temperature

Stability: ≥ 2 years.

Applications

Aquaporin 4 blocker

Functions

Aquaporin 4 channel blocker, IC50 = 3.1 μM. Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI. Increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice. Reduces brain edema when administered after onset of ischemia in rat models.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Option

  • 10 MG
  • 50 MG
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