Terguride, Dopamine D2 agonist (TBI2308)

Description

Product Details

Formal Name: S(+)-N,N-Diethyl-N′([8α]-6-methylergolin-8-yl)urea

Alternate Names: Terguride S(+)

Molecular Formula: C₂₀H₂₈N₄O

Formula Weight: 340.50

CAS Number: 37686-84-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO or in Ethanol.

Storage: RT

Stability: ≥ 2 years.

Applications

Dopamine D2 agonist

Functions

A semi-synthetic ergoline derivative which acts as a partial dopamine D2 agonist and 5HT2B/2C receptor antagonist. Displays antiparkinsonian effects in MPTP-treated cynomolgus monkeys. Partial agonist at recruitment of β-arrestin2 to the D2 receptor. Ameliorates monocrotaline-induced pulmonary hypertension in rats.

Application Procedures

First dissolved in DMSO or in Ethanol, then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.