Welcome to Astor Scientific

New collections added! Learn more

TribioScience  |  SKU: TBI4005-10MG

Talabostat mesylate, Pyroptosis inducer; Inflammasome activator (TBI4005)

$108.00
Shipping calculated at checkout.


Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Payment & Security

Payment methods

  • American Express
  • Apple Pay
  • Diners Club
  • Discover
  • Google Pay
  • Mastercard
  • PayPal
  • Shop Pay
  • Venmo
  • Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.


Product Description


Product Reviews

Customer Reviews

Be the first to write a review
0%
(0)
0%
(0)
0%
(0)
0%
(0)
0%
(0)
TribioScience

Talabostat mesylate, Pyroptosis inducer; Inflammasome activator (TBI4005)

From $108.00

Description

Product Details

Formal Name: ((2R)-1-((2S)-2-Amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid methanesulfonate

Alternate Names: Val-boroPro; PT-100

Molecular Formula: C9H19BN2O3·CH3SO3H

Formula Weight: 310.18

CAS Number: 1510080-09-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Pyroptosis inducer; Inflammasome activator

Functions

Talabostat mesylate is a non-selective inhibitor of the S9 family of serine proteases (IC50’s: DPPIV = <4nM, DPP8 = 4nM, DPP9 = 11nM, QPP = 310nM, FAP = 560nM, PEP = 390nM). Toxicity caused by DPP8/9 inhibition observed with non-selective DPPIV inhibitors limits their use as a diabetes treatment. However, Talabostat displays potent antitumor effects dependent on an intact host immune response. It mediates tumor regression by accelerating the expansion of tumor-specific T cells. Additionally, DPP8/9 inhibition by Talabostat activates the proprotein form of Caspase-1 leading to a proinflammatory form of cell death in monocytes and macrophages – pyroptosis. Pyroptosis induction by DPP8/9 inhibition has been shown to be caused by activation of the inflammasome sensor protein Nlrp1b.

Application Procedures

First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

Option

  • 10 MG
  • 50 MG
View product
close
close
I have a question
sparkles
close
product
Hello! I am very interested in this product.
gift
Special Deal!
sparkles