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TribioScience  |  SKU: TBI3361-10MG

T0901317, LXR agonist (TBI3361)

$90.00
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TribioScience

T0901317, LXR agonist (TBI3361)

From $36.00

Description

Product Details

Formal Name: N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide

Molecular Formula: C17H12F9NO3S

Formula Weight: 481.30

CAS Number: 293754-55-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in ethanol (up to 50 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

LXR agonist

Functions

Potent high affinity liver X receptor (LXRα and β) agonist, EC50~50 nM. Upregulates expression of ABCA1, a reverse cholesterol transporter, resulting in inhibition of cholesterol absorption. Inverse agonist at CAR. T0901317 was also shown to be an FXR agonist at lower potency than LXR thus appropriate controls must be employed when using this compound as a pharmacological tool. Decreases amyloid beta production in a mouse model of Alzheimer’s disease. Inhibits cellular senescence in endothelial cells.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in ethanol (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Option

  • 10 MG
  • 50 MG
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