Synaptamide, Endogenous agonist at GPR110 (TBI1194)

Description

Product Details

Formal Name: N-Docosahexaenoylethanolamide

Alternate Names: DHA-ethanolamide

Molecular Formula: C₂₄H₃₇NO₂

Formula Weight: 371.56

CAS Number: 162758-94-3

Purity: >98%

Formulation: Oil

Solubility: Soluble in DMSO (up to 35 mg/ml).

Storage: -80°C

Stability: ≥ 1 year.

Applications

Endogenous agonist at GPR110

Functions

Anandamide-like lipid mediator produced from DHA in the brain. Stimulates neurite growth, synaptogenesis and glutamatergic synaptic activity in developing hippocampal neurons at 10-100 nM. Potently induces neuronal differentiation of neural stem cells. Promotes growth of cortical axons vial modulation of hedgehog signaling. Binds to and activates orphan receptor GPR110, stimulating cAMP production at low nM concentrations. Reduces LPS-induced TNFα production in cultured microglia cells and ameliorates LPS-induced neuroinflammation in a mouse model.

Application Procedures

First dissolved in DMSO (up to 35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored under inert gas at -80°C for up to 3 months.