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TribioScience | SKU: TBI4925-5MG

SX-682, CXCR1/2 inhibitor (TBI4925)

Name: SX-682, CXCR1/2 inhibitor (TBI4925)
Brand: TribioScience
SKU: TBI4925-5MG
Price: 198.0 USD
Availability: InStock

$198.00

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TribioScience

SX-682, CXCR1/2 inhibitor (TBI4925)

From $198.00

Description

Product Details

Formal Name: [2-[[5-[(4-Fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl]boronic acid

Molecular Formula: C₁₉H₁₄BF₄N₃O₄S

Formula Weight: 467.20

CAS Number: 1648843-04-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

CXCR1/2 inhibitor

Functions

SX-682 is a novel CXCR1/2 inhibitor (IC50s: CXCR1 = 42 nM, CXCR2 = 20 nM). It displayed robust synergistic activity with immune checkpoint blockade against castration resistant prostate cancer. It significantly reduced tumor burden in a Ptenfl/fl/Lkb1fl/fl mouse model of lung squamous cell cancer when used in combination with anti-PD1 therapy. SX-682 significantly inhibited trafficking of neutrophilic myeloid-derived suppressor cells (PMN-MDSCs) enhancing anti-PD1 immune checkpoint blockade, T cell-based immunotherapy, and NK-cell immunotherapy.