Suplatast tosilate, Immunomodulator (TBI2896)

Description

Product Details

Formal Name: [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium

Alternate Names: 4-Methylbenzenesulfonate; IPD 1151T

Molecular Formula: C₁₆H₂₆NO₄S C₇H₇O₃S

Formula Weight: 499.64

CAS Number: 94055-76-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Immunomodulator

Functions

A potent immunoregulator that suppresses IgE production. Suppresses innate immunity by down-regulating TLR2, TLR4 and CD14 gene expression on splenocytes stimulated with LPS and TLR2/TLR4 agonists. Prevents bleomycin-induced pulmonary fibrosis in mouse models. Potent inhibitor of Th2 cells in vivo and together with a Treg cell inhibitor promotes BCG vaccine efficacy against tuberculosis. Antiasthmatic agent effective for antileukotriene nonresponders. Orally active.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml) or in Water (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.