STO-609, CAMKK inhibitor (TBI1036)

Description

Product Details

Formal Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate

Molecular Formula: C₁₉H₁₀N₂O₃ ∙ CH₃COOH

Formula Weight: 314.30 ∙ 60.05

CAS Number: 52029-86-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

CAMKK inhibitor

Functions

Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively). Binds to the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP. Reduces starvation-induced autophagosomal membrane formation. Reverses age-associated decline in bone mass. Stimulates osteoblast formation, inhibits osteoclast differentiation.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.