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TribioScience | SKU: TBI1036-5MG

STO-609, CAMKK inhibitor (TBI1036)

Name: STO-609, CAMKK inhibitor (TBI1036)
Brand: TribioScience
SKU: TBI1036-5MG
Price: 135.0 USD
Availability: InStock

$135.00

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Product Description

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TribioScience

STO-609, CAMKK inhibitor (TBI1036)

From $135.00

Description

Product Details

Formal Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate

Molecular Formula: C₁₉H₁₀N₂O₃ ∙ CH₃COOH

Formula Weight: 314.30 ∙ 60.05

CAS Number: 52029-86-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

CAMKK inhibitor

Functions

Selective inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively). Binds to the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. Important tool for probing distinct CaMK pathways in LTP. Reduces starvation-induced autophagosomal membrane formation. Reverses age-associated decline in bone mass. Stimulates osteoblast formation, inhibits osteoclast differentiation.