Sphingosine, PKC inhibitor (TBI2287)

Description

Product Details

Formal Name: (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol

Alternate Names: D(+)-erythro-1,3-Dihydroxy-2-amino-4-trans-octadecene

Molecular Formula: C₁₈H₃₇NO₂

Formula Weight: 299.50

CAS Number: 123-78-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming).

Storage: -20°C

Stability: ≥ 1 year.

Applications

PKC inhibitor

Functions

Endogenous sphingolipid found in cells esterified as phosphatidylcholine (sphingomyelin) and released by the action of sphingomyelinases. Potent and selective inhibitor of protein kinase C (IC50=1-3 µM). Inhibition is competitive with DAG, phorbol esters and Ca2+. May be phosphorylated by sphingosine kinases producing sphingosine-1-phosphate, a bioactive lipid producing a plethora of biological effects.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 3 months.