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TribioScience  |  SKU: TBI1102-5MG

Sivelestat, Leukocyte elastase inhibitor (TBI1102)

$97.20
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Product Description


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TribioScience

Sivelestat, Leukocyte elastase inhibitor (TBI1102)

From $97.20

Description

Product Details

Formal Name: N-{2-[({4-[(2,2-Dimethylpropanoyl)oxy]phenyl}sulfonyl)amino]benzoyl}glycine sodium

Alternate Names: ONO-5046

Molecular Formula: C20H21N2O7

Formula Weight: 456.45

CAS Number: 127373-66-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 20 mg/ml).

Storage: RT

Stability: ≥ 1 year.

Applications

Leukocyte elastase inhibitor

Functions

Potent and selective leukocyte elastase inhibitor, IC50 = 44 nM. Displays no activity at a variety of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil migration in vitro. Significantly attenuates ischemia-induced spinal cord injury, decreases serum cytokine levels and reduces acute inflammatory lung injury in vivo.

Application Procedures

First dissolved in DMSO (up to 20 mg/ml), then diluted to aqueous buffer.

Option

  • 5 MG
  • 25 MG
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