SB-431542, ALK4,5 and 7 inhibitor (TBI2443)

Description

Product Details

Formal Name: 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Molecular Formula: C₂₂H₁₆N₄O₃

Formula Weight: 384.40

CAS Number: 301836-41-9

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 3 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

ALK4,5 and 7 inhibitor

Functions

Potent and selective ALK4, ALK5 and ALK7 inhibitor (TGFβ superfamily Type I activin receptor-like kinase). (ALK5 IC50 = 94 nM). Inhibits TGFβ-induced proliferation of human osteosarcoma cells. Ehances growth and integrity of embryonic stem cell-derived endothelial cells. A frequently used agent employed in numerous stem cell differentiation protocols. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), or in Ethanol (up to 3 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.