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TribioScience  |  SKU: TBI2338-5MG

SB-216763, GSK-3 inhibitor (TBI2338)

$99.00
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Product Description


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TribioScience

SB-216763, GSK-3 inhibitor (TBI2338)

From $99.00

Description

Product Details

Formal Name: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

Molecular Formula: C19H12Cl2N2O2

Formula Weight: 371.23

CAS Number: 280744-09-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

GSK-3 inhibitor

Functions

Potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM. Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model. Displays neuroprotective effects on cultured neurons. Maintains mouse embryonic stem cells in a pluripotent state. Cell permeable.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Option

  • 5 MG
  • 25 MG
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