SB-203580, p38 MAP kinase inhibitor (TBI2173)

Description

Product Details

Formal Name: 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)imidazoledihydro-imidazole-1-carbonyl]-piperazin-2-one

Molecular Formula: C₂₁H₁₆N₃OSF

Formula Weight: 377.44

CAS Number: 152121-47-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming).

Storage: -20°C

Stability: ≥ 2 years.

Applications

p38 MAP kinase inhibitor

Functions

A potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and δ at 10 μM. A potent inhibitor of inflammatory cytokine production (IC50=15-25 mg/kg in mice and rats) in animal models of arthritis, bone resorption, endotoxin shock and immune function.

Application Procedures

First dissolved in DMSO (up to 100 mg/ml) or in Ethanol (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.