Welcome to Astor Scientific

New collections added! Learn more

TribioScience  |  SKU: TBI4099-10MG

RS-1, RAD51 activator; CRISPR enhancer (TBI4099)

$81.00
Shipping calculated at checkout.


Care information

Display general product information or specific product information using metafields.

Delivery and Shipping

Add some general information about your delivery and shipping policies.

Payment & Security

Payment methods

  • American Express
  • Apple Pay
  • Diners Club
  • Discover
  • Google Pay
  • Mastercard
  • PayPal
  • Shop Pay
  • Venmo
  • Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.


Product Description


Product Reviews

Customer Reviews

Be the first to write a review
0%
(0)
0%
(0)
0%
(0)
0%
(0)
0%
(0)
TribioScience

RS-1, RAD51 activator; CRISPR enhancer (TBI4099)

From $81.00

Description

Product Details

Formal Name: 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide

Molecular Formula: C20H16BrN2O3S

Formula Weight: 524.23

CAS Number: 312756-74-4

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

RAD51 activator; CRISPR enhancer

Functions

RAD51 is a strand exchange protein that is critical for the central steps in homologous recombination (HR) of DNA during double strand break repair. Because HR usually occurs without mutations, it is critically important for maintaining genomic stability. RS-1 is a small molecule that enhances the HR activity of RAD51 by promoting the formation of active presynaptic filaments during repair. At low micromolar levels, it was able to increase cellular resistance of neonatal human dermal fibroblasts to the chemotherapeutic agent cisplatin. HR stimulation in various cell types could lead to temporary protection from DNA damaging agents. RS-1 has been used to exploit the RAD51 overexpression in cancerous cells by inducing lethality via genotoxic RAD51 protein complexes. RS-1 has also been found to a potent enhancer of CRISPR- and TALEN- based gene editing.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Option

  • 10 MG
  • 50 MG
View product
close
close
I have a question
sparkles
close
product
Hello! I am very interested in this product.
gift
Special Deal!
sparkles