Rocaglamide, TNFa inhibitor (TBI2484)

Description

Product Details

Alternate Names: RocA

Molecular Formula: C₂₉H₃₁NO₇

Formula Weight: 505.60

CAS Number: 84573-16-0

Purity: >97%

Formulation: powder

Solubility: Soluble in DMSO

Storage: -20°C

Stability: ≥ 2 years.

Applications

TNFa inhibitor

Functions

Potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200 nM. Completely inhibits IL-4 and IFN-γ production and suppresses IL-2 and TNF-α production at 50 nM in T-cells, without inhibiting AP-1 and NF-κB. Immunosuppresive activity is due to inhibition of cytokine gene expression via blocking NF-AT activity. Has anti-cancer properties via various pathways including ERK inhibition, ATM/ATR-Chk1/Chk2 activation, and p38 and JNK activation.

Application Procedures

First dissolved in DMSO, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.