Riluzole, Sodium channel blocker; Neuroprotective (TBI2815)

Description

Product Details

Formal Name: 2-Amino-6-(trifluoromethoxy)benzothiazole

Molecular Formula: C₈H₅F₃N₂OS

Formula Weight: 234.20

CAS Number: 1744-22-5

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)

Storage: RT

Stability: ≥ 1 year.

Applications

Sodium channel blocker; Neuroprotective

Functions

Riluzole is a clinically useful drug for the treatment of amyotrophic lateral sclerosis (ALS). Riluzole inhibits glutamate release via inactivation of voltage-dependent ion channels, effects expression and signal transduction of glutamate receptors, and facilitates glutamate uptake. It has also been investigated as a treatment for depression and anxiety. Riluzole induced apoptosis in mGluR1-expressing melanoma cells, inhibited cell proliferation in a U87mgglioblastoma model via blockage of glutamate release, and inhibited the growth of brain tumor stem-like cells via downregulation of GLUT3.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in

DMSO or ethanol may be stored at -20°C for up to 2 months.