| Product Name |
Recombinant Mouse TRAIL R2 / CD262 / TNFRSF10B Protein |
| Product Overview |
This recombinant mouse TRAIL R2 / CD262 / TNFRSF10B protein includes amino acids 1-177aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q9QZM4 |
| Recommended Name |
Tumor necrosis factor receptor superfamily member 10B |
| Gene Name |
Tnfrsf10b |
| Synonyms |
DR5;KILLER;Ly98;MK;TRAILR2;TRICK2A;TRICK2B;TRICKB |
| Species |
Mouse |
| Predicted Molecular Mass |
41.8 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
1-177aa |
| Tag |
C-His-Fc |
| Purity |
>85% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Subcellular Location |
Membrane; Single-pass type I membrane protein. |
| Tissue Specificity |
Highly expressed in heart, lung and kidney. |
