| Description |
Recombinant Mouse SEZ6 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Leu20-His922. |
| Purity |
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Accession |
Q7TSK2 |
| Target Symbol |
SEZ6 |
| Synonyms |
SEZ-6; SEZ6; BSRPC; BSRP-C |
| Species |
Mouse |
| Expression System |
HEK293 |
| Tag |
C-His |
| Expression Range |
Leu20-His922 |
| Mol. Weight |
The protein has a predicted MW of 98.8 kDa. Due to glycosylation, the protein migrates to 145-150 kDa based on Tris-Bis PAGE result. |
| Form |
Lyophilized |
| Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Endotoxin |
Less than 1EU per ug by the LAL method. |
| Activity |
Immobilized Mouse SEZ6, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 14.8ng/ml determined by ELISA. Contact us for detailed testing images. |
| Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipping |
Shipped at ambient temperature. |
| Gene Background |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. |
