| Product Name |
Recombinant Mouse PTPN6 Protein |
| Product Overview |
This recombinant mouse PTPN6 protein includes amino acids 207-595aa of the target gene is expressed in Baculovirus-Insect Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P29351 |
| Recommended Name |
Tyrosine-protein phosphatase non-receptor type 6 |
| Gene Name |
Ptpn6 |
| Synonyms |
70Z-SHP;hcp;Hcph;me;Ptp1C;PTPTY-42;SH-PTP1;SHP-1 |
| Species |
Mouse |
| Predicted Molecular Mass |
72.7 kDa |
| Expression System |
Insect Cell |
| Expression Range |
207-595aa |
| Tag |
N-His-GST |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis. |
| Subcellular Location |
Cytoplasm. Nucleus. |
| Protein Family |
Protein-tyrosine phosphatase family, Non-receptor class 2 subfamily |
| Associated Diseases |
Defects in Ptpn6 are the cause of the motheaten (me) or viable motheaten (mev) phenotypes. Mice homozygous for the recessive allelic mutations develop severe defects in hematopoiesis. |
| Tissue Specificity |
Expressed predominantly in hematopoietic cells. |
