| Product Name |
Recombinant Mouse Haptoglobin (Hpt) Protein |
| Product Overview |
This recombinant mouse Haptoglobin (Hpt) protein includes amino acids 19-347aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
Q61646 |
| Recommended Name |
Haptoglobin |
| Gene Name |
Hp |
| Synonyms |
HP; Hp2-Alpha; Alpha-2-Macroglobulin; Zonulin |
| Species |
Mouse |
| Predicted Molecular Mass |
51 kDa |
| Expression System |
E.coli |
| Expression Range |
19-347aa |
| Tag |
N-6His+SUMO |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cardiovascular |
| Target Function |
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. |
| Subcellular Location |
Secreted. |
| Protein Family |
Peptidase S1 family |
| Tissue Specificity |
Expressed by the liver and secreted in plasma. |
