| Description |
Recombinant Mouse GITR Ligand/TNFSF18 Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Thr47-Ser173. |
| Purity |
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Accession |
Q7TS55 |
| Target Symbol |
GITR Ligand/TNFSF18 |
| Synonyms |
TNFSF18; AITRL; TL6; GITRL; GITR Ligand |
| Species |
Mouse |
| Expression System |
HEK293 |
| Tag |
N-hFc |
| Expression Range |
Thr47-Ser173 |
| Mol. Weight |
The protein has a predicted MW of 41.8 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. |
| Form |
Lyophilized |
| Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Endotoxin |
Less than 1EU per ug by the LAL method. |
| Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipping |
Shipped at ambient temperature. |
| Gene Background |
Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important role that GITR plays in regulating immune functions, agonistic stimulation of GITR is a promising therapeutic concept. |
