| Description |
Recombinant Mouse Beta Klotho Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Phe53-Pro994. |
| Purity |
> 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
| Accession |
Q99N32 |
| Target Symbol |
Beta Klotho |
| Species |
Mouse |
| Expression System |
HEK293 |
| Tag |
C-His |
| Expression Range |
Phe53-Pro994 |
| Mol. Weight |
The protein has a predicted MW of 109.91 kDa. Due to glycosylation, the protein migrates to 120-130 kDa based on Tris-Bis PAGE result. |
| Form |
Liquid |
| Formulation |
Supplied as 0.22um filtered solution in PBS (pH 7.4). |
| Endotoxin |
Less than 1EU per ug by the LAL method. |
| Activity |
The affinity constant of 36.97 nM as determined in SPR assay (Biacore T200). Contact us for detailed testing images. |
| Storage |
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Shipping |
Shipped with dry ice. |
| Gene Background |
Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. |
