| Description |
Recombinant Mouse AREG Protein is expressed from HEK293 with hFc tag at the N-Terminus.It contains Val100-Ala248. |
| Purity |
> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Accession |
P31955 |
| Target Symbol |
AREG |
| Synonyms |
Amphiregulin; AR; SDGF; AREG; AREGB; CRDGF; MGC13647 |
| Species |
Mouse |
| Expression System |
HEK293 |
| Tag |
N-hFc |
| Expression Range |
Val100-Ala248 |
| Mol. Weight |
The protein has a predicted MW of 38.6 kDa. Due to glycosylation, the protein migrates to 45-50 kDa based on Tris-Bis PAGE result. |
| Form |
Lyophilized |
| Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Endotoxin |
Less than 1EU per ug by the LAL method. |
| Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
| Shipping |
Shipped at ambient temperature. |
| Gene Background |
Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. AREG is synthesized as a membrane-anchored precursor protein that can engage in juxtacrine signaling on adjacent cells. Alternatively, after proteolytic processing by cell membrane proteases, mainly TACE/ADAM17, AREG is secreted and behaves as an autocrine or paracrine factor. |
