| Product Name |
Recombinant Human Wingless Type MMTV Integration Site Family, Member 4 (WNT4) Protein |
| Product Overview |
This recombinant human Wingless Type MMTV Integration Site Family, Member 4 (WNT4) protein includes amino acids 26-351aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P56705 |
| Recommended Name |
Protein Wnt-4 |
| Gene Name |
WNT4 |
| Species |
Human |
| Predicted Molecular Mass |
40 kDa |
| Expression System |
E.coli |
| Expression Range |
26-351aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Signal Transduction |
| Target Function |
Ligand for members of the frizzled family of seven transmembrane receptors. Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development. Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for normal lung development and for normal patterning of trachael cartilage rings. |
| Subcellular Location |
Secreted, extracellular space, extracellular matrix. |
| Protein Family |
Wnt family |
| Associated Diseases |
46,XX sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL); Mullerian aplasia and hyperandrogenism (MULLAPL) |
