| Product Name |
Recombinant Human Thyroid Stimulating Hormone Receptor (TSHR) Protein |
| Product Overview |
This recombinant human Thyroid Stimulating Hormone Receptor (TSHR) protein includes amino acids 21-413aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P16473 |
| Recommended Name |
Thyrotropin receptor |
| Gene Name |
TSHR |
| Synonyms |
LGR3; HTSHR-I; Thyrotropin Receptor; TSH Receptor |
| Species |
Human |
| Predicted Molecular Mass |
50 kDa |
| Expression System |
E.coli |
| Expression Range |
21-413aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Neuroscience |
| Target Function |
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. |
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. |
| Protein Family |
G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily |
| Associated Diseases |
Hypothyroidism, congenital, non-goitrous, 1 (CHNG1); Familial gestational hyperthyroidism (HTFG); Hyperthyroidism, non-autoimmune (HTNA) |
| Tissue Specificity |
Expressed in thyroide cells (at protein level). Expressed in the thyroid. |
