| Product Name |
Recombinant Human Heat Shock 75kDa, Mitochondrial (HSP75/TRAP1) Protein |
| Product Overview |
This recombinant human Heat Shock 75kDa, Mitochondrial (HSP75/TRAP1) protein includes amino acids 60-704aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
Q12931 |
| Recommended Name |
Heat shock protein 75 kDa, mitochondrial |
| Gene Name |
TRAP1 |
| Synonyms |
TRAP1; HSP90L; TNF Receptor-Associated Protein 1; Tumor necrosis factor type 1 receptor-associated p |
| Species |
Human |
| Predicted Molecular Mass |
84 kDa |
| Expression System |
E.coli |
| Expression Range |
60-704aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Others |
| Target Function |
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. |
| Subcellular Location |
Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix. |
| Protein Family |
Heat shock protein 90 family |
| Tissue Specificity |
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung, placenta and bladder. Expression is highly reduced in bladder cancer and renal cell carcinoma specimens compared to healthy tissues, but it is increased in other type of tumors. |
