| Product Name |
Recombinant Human Eukaryotic Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) Protein |
| Product Overview |
This recombinant human Eukaryotic Tumor Necrosis Factor Ligand Superfamily, Member 18 (TNFSF18) protein includes amino acids 72-177aa of the target gene is expressed in 293F cell.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q9UNG2 |
| Recommended Name |
Tumor necrosis factor ligand superfamily member 18 |
| Gene Name |
TNFSF18 |
| Synonyms |
Tumor necrosis factor ligand superfamily member 18, AITRL, GITRL, hGITRL, TL6 |
| Species |
Human |
| Predicted Molecular Mass |
15/18 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
72-177aa |
| Tag |
N-6His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| Subcellular Location |
Cell membrane; Single-pass type II membrane protein. |
| Protein Family |
Tumor necrosis factor family |
| Tissue Specificity |
Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. |
