| Product Name |
Recombinant Human TNFRSF13B Protein |
| Product Overview |
This recombinant human TNFRSF13B protein includes amino acids 1-165aa of the target gene is expressed in Baculovirus-Insect Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
O14836 |
| Recommended Name |
Tumor necrosis factor receptor superfamily member 13B |
| Gene Name |
TNFRSF13B |
| Synonyms |
Tumor necrosis factor receptor superfamily member 13B, TNFRSF13B, CD267, CVID, CVID2, IGAD2, RYZN, T |
| Species |
Human |
| Predicted Molecular Mass |
45.8 kDa |
| Expression System |
Insect Cell |
| Expression Range |
1-165aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cancer |
| Target Function |
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. |
| Subcellular Location |
Membrane; Single-pass type III membrane protein. |
| Associated Diseases |
Immunodeficiency, common variable, 2 (CVID2); Immunoglobulin A deficiency 2 (IGAD2) |
| Tissue Specificity |
Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells. |
