| Product Name |
Recombinant Human Thrombomodulin (TM/THBD) Protein |
| Product Overview |
This recombinant human Thrombomodulin (TM/THBD) protein includes amino acids 19-515 (473)aa of the target gene is expressed in 293F cell.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P07204 |
| Recommended Name |
Thrombomodulin |
| Gene Name |
THBD |
| Synonyms |
CD141; THBD; BDCA3; THRM; Fetomodulin |
| Species |
Human |
| Predicted Molecular Mass |
70 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
19-515 (473)aa |
| Tag |
C-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cardiovascular |
| Target Function |
Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. |
| Subcellular Location |
Membrane; Single-pass type I membrane protein. |
| Associated Diseases |
Thrombophilia due to thrombomodulin defect (THPH12); Hemolytic uremic syndrome atypical 6 (AHUS6) |
| Tissue Specificity |
Endothelial cells are unique in synthesizing thrombomodulin. |
