| Product Name |
Recombinant Human STXBP1 / UNC18A Protein |
| Product Overview |
This recombinant human STXBP1 / UNC18A protein includes amino acids 1-594aa of the target gene is expressed in Baculovirus-Insect Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
P61764 |
| Recommended Name |
Syntaxin-binding protein 1 |
| Gene Name |
STXBP1 |
| Synonyms |
MUNC18-1;NSEC1;P67;RBSEC1;UNC18 |
| Species |
Human |
| Predicted Molecular Mass |
95.4 kDa |
| Expression System |
Insect Cell |
| Expression Range |
1-594aa |
| Tag |
N-His&GST |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Transport, Cancer |
| Target Function |
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions. |
| Subcellular Location |
Cytoplasm, cytosol. Membrane; Peripheral membrane protein. |
| Protein Family |
STXBP/unc-18/SEC1 family |
| Associated Diseases |
Epileptic encephalopathy, early infantile, 4 (EIEE4) |
| Tissue Specificity |
Brain and spinal cord. Highly enriched in axons. |
