| Product Name |
Recombinant Human Pulmonary Surfactant Associated A1 (SFTPA1) Protein |
| Product Overview |
This recombinant human Pulmonary Surfactant Associated A1 (SFTPA1) protein includes amino acids 21-248 of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitolprior to lyophilization. |
| Target Uniprot Id |
Q8IWL2 |
| Recommended Name |
Pulmonary surfactant-associated protein A1 |
| Gene Name |
SFTPA1 |
| Synonyms |
COLEC4, PSAP, SFTP1, SFTPA, SFTPA1B |
| Species |
Human |
| Predicted Molecular Mass |
28kDa |
| Expression System |
E.coli |
| Expression Range |
21-248 |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS pH 7.4, 0.01% SKL, 5% Trehalose, 1% Mannitol |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Cell Biology |
| Target Function |
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.; (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages. |
| Subcellular Location |
Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film. |
| Protein Family |
SFTPA family |
| Associated Diseases |
Pulmonary fibrosis, idiopathic (IPF); Respiratory distress syndrome in premature infants (RDS) |
