| Product Name |
Recombinant Human SerpinI1 / Neuroserpin Protein |
| Product Overview |
This recombinant human SerpinI1 / Neuroserpin protein includes amino acids 1-410aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q99574 |
| Recommended Name |
Neuroserpin |
| Gene Name |
SERPINI1 |
| Synonyms |
neuroserpin;PI12 |
| Species |
Human |
| Predicted Molecular Mass |
46 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
1-410aa |
| Tag |
C-His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Neuroscience |
| Target Function |
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator (Probable). |
| Subcellular Location |
Secreted. Cytoplasmic vesicle, secretory vesicle lumen. Perikaryon. |
| Protein Family |
Serpin family |
| Associated Diseases |
Encephalopathy, familial, with neuroserpin inclusion bodies (FENIB) |
| Tissue Specificity |
Detected in brain cortex and hippocampus pyramidal neurons (at protein level). Predominantly expressed in the brain. |
