| Product Name |
Recombinant Human SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) Protein |
| Product Overview |
This recombinant human SCO Cytochrome Oxidase Deficient Homolog 2 (SCO2) protein includes amino acids 42-266aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
O43819 |
| Recommended Name |
Protein SCO2 homolog, mitochondrial |
| Gene Name |
SCO2 |
| Synonyms |
Protein SCO2 homolog, mitochondrial, SCO1L |
| Species |
Human |
| Predicted Molecular Mass |
29 kDa |
| Expression System |
E.coli |
| Expression Range |
42-266aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Metabolism |
| Target Function |
Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. |
| Subcellular Location |
Mitochondrion inner membrane; Single-pass membrane protein. |
| Protein Family |
SCO1/2 family |
| Associated Diseases |
Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 1 (CEMCOX1); Myopia 6 (MYP6); Leigh syndrome (LS) |
| Tissue Specificity |
Ubiquitous. |
