| Product Name |
Recombinant Human ROR1 Protein |
| Product Overview |
This recombinant human ROR1 protein includes amino acids 1-403aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization. |
| Target Uniprot Id |
Q01973 |
| Recommended Name |
Inactive tyrosine-protein kinase transmembrane receptor ROR1 |
| Gene Name |
ROR1 |
| Synonyms |
dJ537F10.1;NTRKR1 |
| Species |
Human |
| Predicted Molecular Mass |
43.4 kDa |
| Expression System |
Mammalian Cell |
| Expression Range |
1-403aa |
| Tag |
C-His |
| Purity |
>95% |
| Formulation |
Lyophilized |
| Buffer |
Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Research Area |
Neuroscience |
| Target Function |
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. |
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Cell projection, axon. |
| Protein Family |
Protein kinase superfamily, Tyr protein kinase family, ROR subfamily |
| Associated Diseases |
Deafness, autosomal recessive, 108 (DFNB108) |
| Tissue Specificity |
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. |
