| Product Name |
Recombinant Human Sjogren Syndrome Antigen A2 (SSA2/RO60) Protein |
| Product Overview |
This recombinant human Sjogren Syndrome Antigen A2 (SSA2/RO60) protein includes amino acids 16-376aa of the target gene is expressed in E.coli.The protein is supplied in lyophilized form and formulated in PBSprior to lyophilization. |
| Target Uniprot Id |
P10155 |
| Recommended Name |
RNA-binding protein RO60 |
| Gene Name |
RO60 |
| Synonyms |
RO60; TROVE2; RoRNP; TROVE Domain Family,Member 2; 60kDa Ribonucleoprotein Autoantigen SS-A/Ro; Auto |
| Species |
Human |
| Predicted Molecular Mass |
44 kDa |
| Expression System |
E.coli |
| Expression Range |
16-376aa |
| Tag |
N-6His |
| Purity |
>90% |
| Formulation |
Lyophilized |
| Buffer |
PBS |
| Storage Condition |
1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C. |
| Reconstitution Instruction |
Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%. |
| Applications |
Positive Control; Immunogen; SDS-PAGE; WB |
| Target Function |
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes.; May play roles in cilia formation and/or maintenance. |
| Subcellular Location |
Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. |
| Protein Family |
Ro 60 kDa family |
