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Astor Scientific  |  SKU: ASTP5334

Human RSPO1 (R-Spondin-1) - Recombinant Protein

Molecule: RSPO1
Species: Human
Expression System: Mammalian Cell
Tag: C-His
Expression Range: 1-263aa
$429.99 $549.99
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SDS-PAGE analysis of Human RSPO1 (R-Spondin-1) - Recombinant Protein, showing >90% purity under 15% SDS-PAGE (Reduced)
Astor Scientific

Human RSPO1 (R-Spondin-1) - Recombinant Protein

$429.99 $549.99

Product Overview

Product Name Recombinant Human R-Spondin 1 / RSPO1 Protein
Product Overview This recombinant human R-Spondin 1 / RSPO1 protein includes amino acids 1-263aa of the target gene is expressed in HEK293 Cells.The protein is supplied in lyophilized form and formulated in phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5% trehaloseprior to lyophilization.
Target Uniprot Id Q2MKA7
Recommended Name R-spondin-1
Gene Name RSPO1
Synonyms CRISTIN3;R-Spondin 1;RSPO
Species Human
Predicted Molecular Mass 28.2 kDa
Expression System Mammalian Cell
Expression Range 1-263aa
Tag C-His
Purity >90%
Formulation Lyophilized
Buffer Phosphate buffered saline (pH7.4) containing 0.01% sarcosyl, 5%Trehalose
Storage Condition 1. Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. 2. Avoid repeated freeze-thaw cycles. 3. Store working aliquots at 4°C for up to one week. 4. In general, protein in liquid form is stable for up to 6 months at -20°C/-80°C. Protein in lyophilized powder form is stable for up to 12 months at -20°C/-80°C.
Reconstitution Instruction Briefly centrifuged the vial prior to opening to bring the contents to the bottom. Reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. It is recommended to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. The default final concentration of glycerol is 50%.
Applications Positive Control; Immunogen; SDS-PAGE; WB
Research Area Developmental Biology
Target Function Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1.
Subcellular Location Secreted. Nucleus.
Protein Family R-spondin family
Associated Diseases Keratoderma, palmoplantar, with squamous cell carcinoma of skin and sex reversal (PKKSCC)
Tissue Specificity Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen.

Size

  • 100ug
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